Whenever you reload a saved flight or resume the last flight, always check the fuel quantity that has been loaded.
For example if you make a flight with the default Laminar B737 and save the flight, when you reload the saved flight again, X-Plane 12 seems to reset the fuel to a default amount and does not save the actual fuel remaining when you saved the flight.
This is not consistent between the default aircraft, so always as a matter of proper planning, check the fuel load as part of the pre-fight preparations – don’t assume that the fuel loaded between flights will remain the same even if you did not even start the engines.